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Improving Breast Cancer Risk Assessment to Identify High-Risk Individuals

To advance breast cancer risk modeling/assessment to include known and suspected risk factors, and consider cumulative effects and timing of environmental exposure(s).

As part of our program-directed initiatives, CBCRP intends to fund two types of projects related to science of breast cancer risk assessment.  

With current breast cancer risk assessment tools having limited value for predicting individual risk or for targeting preventive interventions, there is a need to improve risk assessment methods to identify individuals and populations at high risk for breast cancer due to environmental risk factors. 

Download the full RFP or review the two types of projects below.

Full Request for Proposal (pdf)

Application materials are available on proposalCENTRAL.


An informational webinar for this funding opportunity was held on February 17, 2016.  The archived webinar is available here:

This initiative aims to develop and apply novel risk assessment tools that address the limitations in breast cancer risk assessment and better represent the etiology of breast cancer as a complex, multifactorial disease.

Projects may take a variety of approaches to improving breast cancer risk assessment, including modeling and analysis of existing data or targeted studies in vitro or in vivo to provide new data to fill specific knowledge gaps.  

Project guidelines

  1. Projects must include strategies for effectively disseminating and communicating research findings and translating them into guidance for regulatory, medical, public health and individual decision-making.
  2. Projects are encouraged to integrate expertise in risk modeling/assessment and basic and population science, and to include advocates, community stakeholders, and regulators.

Project duration and budget caps for both types of projects

CBCRP intends to fund two types of projects:

  • Modeling and computational projects that do not involve new data collection, each with a maximum direct cost budget of $100,000 and a maximum duration of 2 years
  • Projects involving new data collection and laboratory costs, each with a maximum direct cost budget of $1,000,000 and a maximum duration of 4 years