Biology of the Breast Cell: The Basic Science of the Disease
Overview: Breast cancers originate from normal breast epithelial cells, so critical research is needed to understand the pre-cancerous, causative events of the disease. The underlying genetics of disease heterogeneity seen in the clinic need clarification at the basic science level. We need better and more relevant cell and pre-clinical animal models of breast cancer. The key genetic and molecular signatures of the disease may provide useful biomarkers for better diagnosis and prognosis, so treatments can be individualized and women spared the use of non-effective drugs. The underlying cellular signaling pathways for growth control, cell death, DNA repair, and cell migration/metastasis require exploration to develop into targets for therapy and prevention.
Two of CBCRP's Priority Issues are represented, and the funding data, portfolio summaries, and funded grants are presented in separate sections:
