The CBCRP is committed to supporting research that is on a critical path for practical application. Translational research to be supported by the CBCRP should have the potential for major impact in the areas of (1) prevention, detection, diagnosis, or treatment of breast cancer; (2) improved quality of life for survivors, and/or reduction in the community and social burden caused by the disease in California; or (3) advances in medical practices, health systems changes, health policies, or environmental modifications.
We view translational research as fundamentally different from: (1) exploratory/discovery studies, (2) hypothesis building, and (3) incremental efforts to add to and fill in gaps in knowledge. To distinguish translational research from other types of research funding, the CBCRP will require the applicant to present a "critical path" that maps how the project fits along a defined research continuum leading to practical applications. We encourage applications in translational research from all disciplines, including: basic/clinical sciences, behavioral/ social sciences, public health/community-based health sciences, and health policy.
Specifically, the CBCRP's Translational Research Award is designed to support new and ongoing research projects that are able to:
- Clearly describe the "translational bridge" elements—(1) the research discovery to be translated, (2) how the discovery will be applied, (3) the end point targeted, and (4) potential individual or population-level impact
- Define key steps or milestones on a critical pathway from the present level of research knowledge to the practical application
- Build on progress already made by the research team to advance the translation process
- Identify discrete barriers to this progress and detailed strategies to overcome them
- Employ a unique perspective and innovative research methods
- Include plans for evaluating the process and outcome of the translational effort
- Optional: include collaborations that allow diverse disciplines to contribute to the translational effort
Translational Research Award Details:
- 3 years maximum duration
- Award amounts of greater than $750,000 total direct costs will be considered only in exceptional circumstances
To submit a full Translational Research Award application, a letter of intent (LOI) must be submitted by August 29, 2013. The translational projects described in the LOI must:
- Represent a significant leap from incremental knowledge-gathering to a practical application (a translational endpoint)
- Involve the study of human subjects or directly enable a follow-up study in human subjects
- Not be fully supported by other funding
Letters of intent will be evaluated by the CBCRP's council. The CBCRP will invite a limited number of applicants to compete for a full research award each year, based on the quality of LOIs and availability of funds. LOI decisions and invitations to submit a full grant application will be communicated to PIs in October.